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human kidney proximal tubule epithelial cell line hk  (ATCC)


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    ATCC human kidney proximal tubule epithelial cell line hk
    Human Kidney Proximal Tubule Epithelial Cell Line Hk, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 4455 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/human+kidney+proximal+tubule+epithelial+cell+line+hk/pmc12684932-138-11-22?v=ATCC
    Average 99 stars, based on 4455 article reviews
    human kidney proximal tubule epithelial cell line hk - by Bioz Stars, 2026-08
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    Fig. 4. Mitochondrial Morphology in Renal Proximal Tubular <t>Epithelial</t> Cells Observed by Transmission Electron Microscopy. Representative images of mito chondrial morphology in renal proximal tubular epithelial cells were captured using transmission electron microscopy at ×20,000 magnification. (A) Control group exhibiting normal mitochondrial structure. (B) Palmitate group displaying mitochondrial swelling, deformation, and vacuolar degeneration (red arrows). (C) Palmitate + Dapagliflozin (DAPA) group, where mitochondrial swelling and damage were reduced (red arrows). (D) DAPA group showing normal mitochon drial morphology.
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    Fig. 4. Mitochondrial Morphology in Renal Proximal Tubular Epithelial Cells Observed by Transmission Electron Microscopy. Representative images of mito chondrial morphology in renal proximal tubular epithelial cells were captured using transmission electron microscopy at ×20,000 magnification. (A) Control group exhibiting normal mitochondrial structure. (B) Palmitate group displaying mitochondrial swelling, deformation, and vacuolar degeneration (red arrows). (C) Palmitate + Dapagliflozin (DAPA) group, where mitochondrial swelling and damage were reduced (red arrows). (D) DAPA group showing normal mitochon drial morphology.

    Journal: Journal of diabetes and its complications

    Article Title: Dapagliflozin has protective effects on palmitate-induced renal tubular epithelial cells by enhancing mitochondrial function and reducing oxidative stress.

    doi: 10.1016/j.jdiacomp.2024.108930

    Figure Lengend Snippet: Fig. 4. Mitochondrial Morphology in Renal Proximal Tubular Epithelial Cells Observed by Transmission Electron Microscopy. Representative images of mito chondrial morphology in renal proximal tubular epithelial cells were captured using transmission electron microscopy at ×20,000 magnification. (A) Control group exhibiting normal mitochondrial structure. (B) Palmitate group displaying mitochondrial swelling, deformation, and vacuolar degeneration (red arrows). (C) Palmitate + Dapagliflozin (DAPA) group, where mitochondrial swelling and damage were reduced (red arrows). (D) DAPA group showing normal mitochon drial morphology.

    Article Snippet: Human kidney proximal tubular epithelial cell line, HK-2, was purchased from the American Type Culture Collection (ATCC) (Manassas, VA, USA).

    Techniques: Transmission Assay, Electron Microscopy, Control

    STAP2 regulates the advancement of renal fibrosis through the HSP27-PI3K/AKT signaling pathway. After various factors lead to renal injury, the upregulation of STAP2 promotes the interaction between STAP2 and HSP27, further enhancing the phosphorylation of HSP27 and activation of the PI3K/AKT signaling pathway, which results in the loss of epithelial phenotype in epithelial cells, activation of fibroblasts and ultimately results in renal interstitial fibrosis

    Journal: Journal of Translational Medicine

    Article Title: STAP2 promotes the progression of renal fibrosis via HSP27

    doi: 10.1186/s12967-024-05776-6

    Figure Lengend Snippet: STAP2 regulates the advancement of renal fibrosis through the HSP27-PI3K/AKT signaling pathway. After various factors lead to renal injury, the upregulation of STAP2 promotes the interaction between STAP2 and HSP27, further enhancing the phosphorylation of HSP27 and activation of the PI3K/AKT signaling pathway, which results in the loss of epithelial phenotype in epithelial cells, activation of fibroblasts and ultimately results in renal interstitial fibrosis

    Article Snippet: The China Center for Type Culture Collection (Wuhan, China) provided the normal human kidney proximal tubule epithelial cell line (HK-2), which was grown in a DMEM/F12 medium (#G4610-500ML, Servicebio, Wuhan, China) supplemented with 10% fetal bovine serum (FBS, Gibco, USA).

    Techniques: Phospho-proteomics, Activation Assay